Bazıları ilaç tedavisi olmadan HIV'i kontrol edebiliyor
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Clue to how some 'control' their HIV without medication
01/14/2011 00:00:00
Around one in 300 people with HIV are "controllers", and scientists want toreplicatehow their bodies behave.
Writing in Science, US researchers say differences in five amino acids in a protein called HLA-B arekey.
But a UK expert said there was still a "long way" to go before avaccineor a new drug for HIV could be developed.
HIV "controllers" were first identified almost 20 years ago. They are able tosuppressviral replication with theirimmunesystem, keeping viralloadat extremely low levels, without using anti-retroviraldrugs.
It was already known that certain genes involved with the HLA system were important for HIV control. But scientists had not identified which genes were involved or how they acted.
Drag and drop
The researcherscarried outa genome-wideassociationstudy of the genetic make-up of almost 1,000 controllers and 2,600 people withprogressiveHIV.
Around 300 points were found to be associated with immune control of HIV, all in regions of chromosome six that code for HLA proteins.
Scientists were then able topinpointspecificamino acids and identified the five in the HLA-B protein as playing the key role.
HLA-B is part of theprocessby which the immune systemrecognizesanddestroysvirus-infected cells.
Part of the protein called abindingpocket"drags and drops" peptides from inside the virus onto the cell membrane.
These thenmark outthe cell for destruction by CD8 "killer" T cells in the immune system.
All five of the amino acids identified by researchers are in the binding pocket.
Scientists from Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University carried out the work.
Bruce Walker of the Ragon Institute at Massachusetts General Hospital, one of the lead authors of the paper, said: "We found that, of the 3bn nucleotides in the human genome, just ahandfulmake the difference between those who can stay healthyin spite ofHIV infection and those who, without treatment, will develop Aids.
"Knowing how an effective immuneresponseagainst HIV isgeneratedis an important step toward replicating that response with a vaccine.
"We have a long way to go before translating this into a treatment for infected patients and a vaccine to prevent infection, but we are an important step closer."
Bazıları ilaç tedavisi olmadan HIV'i kontrol edebiliyor - Clue to how some 'control' their HIV without medication
Around one in 300 people with HIV are "controllers", and scientists want toreplicatehow their bodies behave.
Writing in Science, US researchers say differences in five amino acids in a protein called HLA-B arekey.
But a UK expert said there was still a "long way" to go before avaccineor a new drug for HIV could be developed.
HIV "controllers" were first identified almost 20 years ago. They are able tosuppressviral replication with theirimmunesystem, keeping viralloadat extremely low levels, without using anti-retroviraldrugs.
It was already known that certain genes involved with the HLA system were important for HIV control. But scientists had not identified which genes were involved or how they acted.
Drag and drop
The researcherscarried outa genome-wideassociationstudy of the genetic make-up of almost 1,000 controllers and 2,600 people withprogressiveHIV.
Around 300 points were found to be associated with immune control of HIV, all in regions of chromosome six that code for HLA proteins.
Scientists were then able topinpointspecificamino acids and identified the five in the HLA-B protein as playing the key role.
HLA-B is part of theprocessby which the immune systemrecognizesanddestroysvirus-infected cells.
Part of the protein called abindingpocket"drags and drops" peptides from inside the virus onto the cell membrane.
These thenmark outthe cell for destruction by CD8 "killer" T cells in the immune system.
All five of the amino acids identified by researchers are in the binding pocket.
Scientists from Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University carried out the work.
Bruce Walker of the Ragon Institute at Massachusetts General Hospital, one of the lead authors of the paper, said: "We found that, of the 3bn nucleotides in the human genome, just ahandfulmake the difference between those who can stay healthyin spite ofHIV infection and those who, without treatment, will develop Aids.
"Knowing how an effective immuneresponseagainst HIV isgeneratedis an important step toward replicating that response with a vaccine.
"We have a long way to go before translating this into a treatment for infected patients and a vaccine to prevent infection, but we are an important step closer."
http://www.bbc.co.uk/news/health-11692798